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Mayo Clinic Researchers: Low Cost HER2 Test Sufficient for Most Women

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More than 207,000 American women will learn this year that they have breast cancer. The lucky ones will find out early, when breast cancer is the most treatable. If you are one of these women, tests will likely determine the treatment that is best for your type of cancer.

One of these tests determines if a woman has HER2-positive breast cancer. HER2 stands for Human Epidermal growth factor Receptor 2. Studies show that roughly one-quarter of all breast cancer patients are HER2-positive.

It is critical for your oncologist to determine if your cancer is HER2-positive because these tumors tend to grow and spread more aggressively therefore, require different therapy. Most often the drug Herceptin is used in additional to other breast cancer treatments.

Currently, many physicians use as many as three different tests to determine HER2 status. This practice is unnecessary for most breast cancer patients and adds considerable expense to treatment, says a recent research article published in the Journal of Clinical Oncology.

Mayo Clinic researchers believe a single, low cost molecular test known as ImmunoHistoChemistry (IHC), is enough for most patients to determine HER2 status. If the test is positive, Herception should be used. However, if the test is negative, a second test to check for HER2 genes should be ordered, the study says.

“It makes economic sense for oncologists to use the IHC test first,” says the study’s lead investigator, Edith Perez, M.D., a breast cancer researcher at the Mayo Clinic’s Florida campus. “Our data are very important for clinical practice and will likely change how these tests are ordered, resulting in savings for individual patients as well as for the nation.”

Researchers found that IHC and another more expensive test, a Fluorescence In Situ Hybirdization (FISH) analysis, equally predicted if a patient would benefit from Herceptin. A third test to measure chromosome 17 copy number was not found to be helpful at all. Some clinicians are using all three tests to determine HER2 status.

The researchers said there has been longstanding confusion over HER2 testing.

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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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