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I eat a very healthy, diverse and mostly organic diet but I also take vitamin C which is constantly filtered out of your system and is only absorbed when needed so I try to keep a consistant supply going. I also take vitamin D because I live in the northern hemisphere and the sun isn't very strong from fall to spring. I take 400iu from spring to summer and up it to 800 through the winter months when the sun is weakest. Just a note, flu season starts in the fall - this is when the sun drops below the equator and everyone is getting less nautrally produced vitamin D than they are used to. It is also known that taking vitamin D can protect you from colds and flus (yes, even H1N1 - just google it) as well as preventing diabetes, depression, chroic pain, cancer etc, etc, etc. so that is the one supplement you should take if you have to choose only one. Just make sure it is a good quality supplement - there are many organic choices now. Other than that, look at your diet, if you are finding you are deficient in eating your nutrients naturally, then THOSE are the ones you should supplement.