I had the same problem with adderall xr and pristiq. The extreme sleepiness and too calm to move feeling is an interaction between adderall xr and pristiq. The norepinephrine re uptake property in the pristiq and the NRI property in the adderall will actually cancel each other out, resulting in that really weird tired/calm feeling. You didn't notice it for a couple of weeks because it takes a couple of weeks for the pristiq to create a constant blood plasma level. Therefore, since you were taking the medications at opposite times, they did not start to interact for a couple of weeks. My doctor switched me to adderall IR twice daily and I no longer experience this side effect at all.
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I had the same problem with adderall xr and pristiq. The extreme sleepiness and too calm to move feeling is an interaction between adderall xr and pristiq. The norepinephrine re uptake property in the pristiq and the NRI property in the adderall will actually cancel each other out, resulting in that really weird tired/calm feeling. You didn't notice it for a couple of weeks because it takes a couple of weeks for the pristiq to create a constant blood plasma level. Therefore, since you were taking the medications at opposite times, they did not start to interact for a couple of weeks. My doctor switched me to adderall IR twice daily and I no longer experience this side effect at all.
September 8, 2015 - 11:25amThis Comment
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