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Thanks for posting this, good question. Methotrexate is used for a number of different illnesses and like any drug, it has its side effects. Liver damage (or hepatic toxicity) is one of them. With that being said though, it is important that when you are on any drug regimen that you are being closely monitored by your doctor. A simple blood test to check your liver enzymes can help ease your mind about causing any damage. Usually, at the first sign of elevated enzymes your PCP will most likely decrease the amount of medication or stop the treatment and consider another drug of choice. Is there a reason why you seem worried about this? Or is it based on what you have read about hepatic toxicity in your research?
Since Methotrexate has the potential for liver damage, I would recommend consulting with your PCP if you have any previous history with your liver. If he or she still decides to add this to your drug regimen, proceed with care. As a rule of thumb it is a great idea to familiarize yourself with all drugs you may be on for potential drug interaction.

You can do a little more reading about it on this site:
AmericanFamilyPhysician

Hope to have helped!

June 4, 2009 - 5:19am

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