I wanted to see what the response was to my initial observations so here is some more anecdotal but extremely interesting stuff surrounding resveratrol. I know a guy who due to misadventures during his somewhat involuntary stay in Vietnam ended up with Hepatitis c. He also suffers from arthritus, had a liver transplant , diabetes, was seriously fat, and has diabetes. He is the only person of a group of 12 people who had liver tranplants when he did. So thats some backgound although he has made efforts to improve his health with positve results.
He started to take resveratrol. He started to loose a steady 4.5 lbs a month and his blood sugars were still elevated but stable. His doctor wanted to know what he was doing. But all he was doing was taking the same stuff that I do. Also there was a modest regrowth of hair on our balding heads.
Also a cheap substance called Piperin has been found to radicly improve the bioavalability of resveratrol which is short lived in the bloodstream.
Here is a synopsis of the study:Mol Nutr Food Res. 2011 Jun 29. doi: 10.1002/mnfr.201100117. [Epub ahead of print]
Enhancing the bioavailability of resveratrol by combining it with piperine.
Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N.
Source
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Abstract
Scope: Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin shown to possess a multitude of health-promoting properties in pre-clinical studies. However, the poor in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans. In this study, we examined the hypothesis that piperine will enhance the pharmacokinetic parameters of resveratrol via inhibiting its glucuronidation, thereby slowing its elimination. Methods and results: Employing a standardized LC/MS assay, we determined the effect of piperine co-administration with resveratrol on serum levels resveratrol and resveratrol-3-O-β-D-glucuronide in C57BL mice. Mice were administered resveratrol (100 mg/kg; oral gavage) or resveratrol (100 mg/kg; oral gavage)+piperine (10 mg/kg; oral gavage), and the serum levels of resveratrol and resveratrol-3-O-β-D-glucuronide were analyzed at different times. We found that the degree of exposure (i.e. AUC) to resveratrol was enhanced to 229% and the maximum serum concentration (C(max) ) was increased to 1544% with the addition of piperine. Conclusion: Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol. However, further detailed research is needed to study the mechanism of improved bioavailability of resveratrol via its combination with piperine as well as its effect on resveratrol metabolism.
I ordered some I am sure there are some less desirable aspects of piperin but I intend to follow it a bit further. I have ordered some from swansons.com for about 3.50 a bottle . If it turns out to be inappropriate then I will chuck them. I think I will take my picture once a day and see if there is any change that can be seen, besides the ungraceful effects of age and gravity. It will be interesting.
There are other things that I take which amazingly received the approval of my regular doctor (who is smarter than most). Things like fish oil, a baby aspirin a day and more. It should make sense on both a scientific and your own personal opinion of the results and how you feel when you stop taking the supplement. It's easy to be overenthusiastic
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I wanted to see what the response was to my initial observations so here is some more anecdotal but extremely interesting stuff surrounding resveratrol. I know a guy who due to misadventures during his somewhat involuntary stay in Vietnam ended up with Hepatitis c. He also suffers from arthritus, had a liver transplant , diabetes, was seriously fat, and has diabetes. He is the only person of a group of 12 people who had liver tranplants when he did. So thats some backgound although he has made efforts to improve his health with positve results.
He started to take resveratrol. He started to loose a steady 4.5 lbs a month and his blood sugars were still elevated but stable. His doctor wanted to know what he was doing. But all he was doing was taking the same stuff that I do. Also there was a modest regrowth of hair on our balding heads.
Also a cheap substance called Piperin has been found to radicly improve the bioavalability of resveratrol which is short lived in the bloodstream.
Here is a synopsis of the study:Mol Nutr Food Res. 2011 Jun 29. doi: 10.1002/mnfr.201100117. [Epub ahead of print]
Enhancing the bioavailability of resveratrol by combining it with piperine.
Johnson JJ, Nihal M, Siddiqui IA, Scarlett CO, Bailey HH, Mukhtar H, Ahmad N.
Source
Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.
Abstract
Scope: Resveratrol (3,5,4'-trihydroxystilbene) is a phytoalexin shown to possess a multitude of health-promoting properties in pre-clinical studies. However, the poor in vivo bioavailability of resveratrol due to its rapid metabolism is being considered as a major obstacle in translating its effects in humans. In this study, we examined the hypothesis that piperine will enhance the pharmacokinetic parameters of resveratrol via inhibiting its glucuronidation, thereby slowing its elimination. Methods and results: Employing a standardized LC/MS assay, we determined the effect of piperine co-administration with resveratrol on serum levels resveratrol and resveratrol-3-O-β-D-glucuronide in C57BL mice. Mice were administered resveratrol (100 mg/kg; oral gavage) or resveratrol (100 mg/kg; oral gavage)+piperine (10 mg/kg; oral gavage), and the serum levels of resveratrol and resveratrol-3-O-β-D-glucuronide were analyzed at different times. We found that the degree of exposure (i.e. AUC) to resveratrol was enhanced to 229% and the maximum serum concentration (C(max) ) was increased to 1544% with the addition of piperine. Conclusion: Our study demonstrated that piperine significantly improves the in vivo bioavailability of resveratrol. However, further detailed research is needed to study the mechanism of improved bioavailability of resveratrol via its combination with piperine as well as its effect on resveratrol metabolism.
I ordered some I am sure there are some less desirable aspects of piperin but I intend to follow it a bit further. I have ordered some from swansons.com for about 3.50 a bottle . If it turns out to be inappropriate then I will chuck them. I think I will take my picture once a day and see if there is any change that can be seen, besides the ungraceful effects of age and gravity. It will be interesting.
There are other things that I take which amazingly received the approval of my regular doctor (who is smarter than most). Things like fish oil, a baby aspirin a day and more. It should make sense on both a scientific and your own personal opinion of the results and how you feel when you stop taking the supplement. It's easy to be overenthusiastic
August 17, 2011 - 7:28pmThis Comment
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