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High Prolactin Level: Why? Do I Need an Endo Consult?

By Anonymous May 16, 2012 - 2:30pm
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My GP just did a series of lab levels that showed that my prolactin level is off the chart high--126.7 when normal is in the 4.8-23.3 league. I am not producing breast milk. Do I need an endocrinology referral? What could this be due to?

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I also am still being treated for hypothyroidism. It may be the case that the combo of still unoptimally treated/undertreated thyroid and halperidol is what is going on. Thanks for all your help. I will keep you abreast of what is going on.

May 17, 2012 - 5:40pm

Hi Cheryl,

Don't stop taking your daily dose of halperidol until you have met with the physician who prescribed it. Maybe, you can be switched to another medication.

Indeed, if your doctor tells you to stop taking halperidol, you will be told to wait and then be retested.

Please keep us updated on what happens.


May 17, 2012 - 4:26pm

I have been taking ten mg per day of halperidol for the past two months. Owing to the RN's comments on meds being a potential cause, this may be the reason. I have an appt next week with MD who prescribes this. Maybe it is time to stop the halperidol, wait, and then retest?

May 16, 2012 - 9:36pm

Hello Anonymous,

Has your physician ordered any further diagnostic testing, such as an MRI? Has a referral to see an endocrinologist been suggested?

One cause of high prolactin levels is a prolactinoma, which is a non-cancerous tumor of the pituitary gland. The pituitary gland is a small gland which produces prolactin. It is located just below the brain. A prolactinoma is diagnosed by elevated prolactin levels and a evidence of a mass in the pituitary gland, as seen on an MRI scan.

Certain medications, such as the major tranquilizers trifluoperazine and haloperidol, Reglan, which is prescribed to treat GERD, Methyldopa and Reserpine block the effects of dopamine at the pituitary gland or can deplete dopamine stores in the brain thus causing the pituitary to secrete more prolactin.

Other tumors of the pituitary gland, like Cushing's syndrome, breast stimulation and hypothyroidism can cause high prolactin levels.

I think further testing is necessary to make a diagnosis.


May 16, 2012 - 4:27pm
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Anonymous (reply to Maryann Gromisch RN)

i agree. I, also, have a high prolactin level at about 52.7...However, I'm still producing milk, and I believe that it is due to sleeping on my stomach. I got an MRI, and it didnt show any tumors on my pituitary gland. Still, it becomes troubling if you want to have children, not to mention the fatigue, weight gain, and overall feeling of being unbalanced. thanks for the post...

May 16, 2012 - 6:24pm
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