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I have been told that i have mixed connective tissue disease, but I do not have the markers for it, just the symptoms. Anyone else experience this?

By Anonymous January 16, 2009 - 2:12pm
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I have seen several rheumatologists, and had every test done under the sun. My symptoms..fatigue, muscle pain, loss of flexibility, and others, seem to fit Mixed connective tissue, but the tests don't really confirm it. Could something else be going on here? I am currently being tested for celiac disease. What other kind of practitioner could I consult? I believe the "lens" that a rheumatologist looks through can sometimes limit them to only certain possibilities.

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Anon, have you been tested for fibromalagia? it shares many of the symptoms you're discussing. Here is a page that discusses fibromalagia:


I'm interested that you're being tested for celiac disease, because the Mayo Clinic lists these primary symptoms of celiac disease:

Intermittent diarrhea
Abdominal pain

And their secondary list of celiac symptoms is this:

Irritability or depression
Stomach upset
Joint pain
Muscle cramps
Skin rash
Mouth sores
Dental and bone disorders (such as osteoporosis)
Tingling in the legs and feet (neuropathy)

And here's the symptoms Mayo lists for mixed connective tissue disease:

Muscle weakness
Joint pain
Joint swelling
Swollen fingers
Mild fever
Raynaud's phenomenon — blood vessel spasms that interrupt blood flow to the fingers, toes, ears and nose

You hadn't mentioned anything digestive, is that also going on with you?

Here's that page on celiac disease:


and on mixed connective tissue disease:


Please come back and let us know more about what's going on; how long you've had your symptoms, and what they've ruled out. Maybe we can help you more with some research or with one of our experts.

January 19, 2009 - 9:30am
HERWriter Guide

Hi Anon

Thank you for your question - I'm sorry you're dealing with so much.

Mixed connective tissue disease is quite rare and is an disease of the auto immune system. You are very correct in wondering if you actually have it because it is considered an "overlap" disease, meaning it has many of the same qualities as other autoimmune conditions like lupus, scleroderma and polymyositis. Many people initially get a diagnosis of lupus until the symptoms start changing and eventually a firm diagnosis of mixed connective tissue disease is reached.

Have you been tested for lupus, scleroderma and polymyositis yet? If not, you might want to suggest it to your doctor.

You might also want to consider seeing an endocrinologist to rule out an issue with your glands, hormones and thyroid.

When did your symptoms first start?

January 16, 2009 - 3:34pm
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