ask: I'm told no alcohol while on methotrexate. How strict is this? As long I I have my liver funtion tested periodically isn't it safe. I can't imagine that permanent damage qould occur within one month of having drinks one day a week. anyone have insite?

Anon - According to the physician guide for monitoring methotrexate use in patients, there is no scientific data showing what amount of alcohol could be safely consumed. Most physicians believe that alcohol consumption in any amount is an absolute contraindication. In other words, not even a small amount is considered okay.

The literature accompanying methotrexate states that alcohol is not recommended or condoned. Some doctors believe that taking methotrexate in conjunction with alcohol, especially regular alcohol use, is extremely dangerous and can cause liver damage and cirrhosis.

In short, the warnings that you should not consume any alcohol while on this medication are strict and serious, and "having drinks one day a week" could put your health at serious risk. It would be advisable to take the warnings seriously, and to go so far as to also refrain from products in your home that may contain alcohol, such as mouthwash.

Pat