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Yeast Infection: Which medicine (OTC) is the best?

By August 21, 2009 - 7:13am
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There are so many choices for over-the-counter medications for yeast infections, and I understand the difference between the suppositories, creams and wipes.

I'm curious, though, to know which of the suppositories are the best, or how do we find out? For instance, Monistat has the 7 day, 3 day, and two versions of a 1-day that contain different types of medication. Most of them have the active ingredient miconazole nitrate, but one of the 1-Day is tioconazole.

My questions are:
1. Are there any clinical studies that says one active ingredient works better?
2. Any research that says the 7 day, 3 day or 1 day treatments work better?


Add a Comment12 Comments

EmpowHER Guest

Whatever you do, I don't suggest the monistst brand!! My poor vag was in hell! Burn and painful itching.

November 6, 2016 - 10:25am
EmpowHER Guest

Tioconazole is an antifungul targeted specifically to vaginal yeast infections whereas miconazole is a broad spectrum antifungal can treat several types of fungi infections not specifically vaginal

April 29, 2016 - 10:18am
EmpowHER Guest

Tioconazole caused an allergic reaction for me, probably because it's stronger.

April 13, 2016 - 5:49am
EmpowHER Guest

Once you start to feel like you may be getting a yeast infection, you need to take a supplement right away - as it will kill the Candida yeast that causes yeast infections. It wont cause harm. Right when I get the small feeling that I may be getting a yeast infection, I take 2 Lady Soma Candida Cleanse pills and then two more at night. Usually, I wont get an infection at all. If I do not take them soon enough, and I end up with a yeast infection, I just take 4 right away, and it clears up in 24 hours. Its natural and does not have side effects.

February 7, 2016 - 2:09pm
EmpowHER Guest

Folks here are missing the fact that all 1 day treatments are less effective than longer treatments. 1day treatments are a gamble and 3 day courses are what my doctors have always recommended.

Yes longer treatments are cheaper, but the more stubborn the infection or more often a woman gets these infections, the longer the course of treatment. I used to get yi's chronically, and once took a two one day traetments, then a three day and finally an 8 day. If I'd taken a 5 day in the first place it might have been over quick.

Anyway, I've tried the 1 days several times and never once has it cured the infection. Every one is different.

September 19, 2015 - 6:08am
EmpowHER Guest

From my experience I have always gotten a yeast infection after my periods. I used the Miconozole 1 day treatment, not only did it burn it actually chapped my labia's and cause a tear. It also did not cute my yeast infection. The next day I bought some Tioconozole 1 day treatment. No burning slight itching but the next morning a I had no more symptoms of the infection. I do not understand why anyone would want to treat themselves for a yeast infection 3 or even worse 7 days. If you ate on a budget than I suppose you can buy the lon get treatments but from experience it made me miserable waiting that long.

May 9, 2015 - 9:09pm
EmpowHER Guest

I have found that the miconazole treatments do work but they burn. I have tried the one day triconazole treatment and it worked great, plus no burning! It's just a bit more expensive.

February 1, 2013 - 11:45am
EmpowHER Guest

Nice thread we have here. I suggest to have a wheat free diet consist of yogurt. That would help to balance your body's god and bad bacteria that cause candida. Thats my secret in candida treatment


January 5, 2011 - 6:57am
EmpowHER Guest
Anonymous (reply to Anonymous)

How does that answer the question at all?

December 18, 2014 - 10:21pm
HERWriter Guide

Hi Veronica

It's hard to say which medication works best for an individual women as they have their individual preferences based on their experiences/cost etc.

But the one day tioconazole is considered by most to be better - it is certainly stronger, hence only needing a one day application. But it's more expensive so some women choose the miconazole and suffer through the 3 or 7 day versions. The problem is that so many people stop taking it after 3 or 4 days and fail to complete the regime, causing the infection to come back. But both are anti-fungal and they both work but tioconazole is generally considered better.

From Wiley Interscience - "A total of ninety-nine patients, of whom eighty-six had fungal infections of the skin and thirteen erythrasma, took part in a double blind comparison of the efficacy and acceptability of tioconazole and miconazole creams applied twice daily. The duration of treatment was 4 weeks.

Of the patients available for review upon completion of treatment, twenty-three of thirty-four patients (68%) treated with tioconazole and twenty-one of thirty-eight patients (55%) treated with miconazole were cured clinically and mycologically. Of the patients available for follow-up 4 weeks later, nineteen of twenty-one patients (90·5%) treated with tioconazole and twelve of fifteen patients (80%) treated with miconazole remained free from infection.

Statistical analysis showed that tioconazole achieved a significantly higher mycological cure rate than miconazole. There was no significant difference between the two creams in clinical or overall cure rates."

This study was from St John's Hospital, London, England.

So if women can afford the one day treatment, it's the better option but either will work.

There is also a single pill called Diflucan that is made with fluconazole and saves all the mess! However, it can cause a little nausea in some women (I've taken it and had no side effects) and is by prescription only.

Has this helped?

August 22, 2009 - 11:11am
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