Alzheimer's Disease Causes & Risks

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Alzheimer's Disease Guide

Alison Beaver Guide

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Causes

The cause is not yet known. Studies suggest that two main mechanisms are involved with the development of Alzheimer's disease:

  • Plaques—abnormal deposits of a substance called beta amyloid in different areas of the brain
  • Neurofibrillary tangles—twisted fibers within nerve cells

Risk Factors

Factors that increase your chance of Alzheimer's disease include:

  • Age: 65 and older
  • Previous serious, traumatic brain injury
  • Lower educational achievement
  • Down's syndrome
  • Down's syndrome in a first-degree relative
  • Women under 35 who give birth to a child with Down's syndrome
  • Smoking
  • Family history of Alzheimer's disease
  • Presence of a certain variety type of apolipoprotein (APOE-e4)
  • Depression
  • Elevated levels of homocysteine
  • Heart disease

Researchers are studying the following to see if they are related to Alzheimer's disease:

  • Poor nutrition and vitamin deficiency in childhood
  • Exposure to electromagnetic fields
  • Excess metal in the blood, especially zinc, copper, aluminum, and iron
  • Certain viral infections
  • Diabetes
  • High Cholesterol

Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. Copyright © 2012 EBSCO Publishing All rights reserved.

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