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Causes
Reiter's syndrome is triggered by certain infections in a genetically susceptible person. The infection often starts in the urinary or genital tract, and is usually caused by the bacterium Chlamydia trachomatis.Chlamydia is passed between people through sexual activity.
The infection can also begin in the digestive system. In these cases, the infection occurs after eating food tainted with bacteria, usually Shigella , Salmonella , Yersinia , or Campylobacter .
About 1 to 4 weeks after the infection, a susceptible person may develop Reiter’s syndrome. Doctors do not know why some people develop the disease and others do not. But most patients with the condition carry a specific genetic factor called HLA-B27 (or the B27 gene).
Risk Factors
A risk factor is something that increases your chance of getting a disease or condition. Risk factors for Reiter's syndrome include:
- Family members with Reiter's syndrome
- Inheriting the genetic trait associated with Reiter’s syndrome (HLA-B27)
- Sex: male
- Sexual orientation: homosexual or bisexual man
- Age: 20 to 40
- Having a sexually-transmitted disease
- Recent new sexual partner
- Eating improperly handled food
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition. Copyright © 2026 EBSCO Publishing All rights reserved.