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Schilder's Disease

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Schilder's Disease Definition

Definition

X-linked adrenoleukodystrophy (ALD) is a rare inherited genetic disorder. There have been 34 types of ALD described. X-linked ALD is the most common category. ALD results in degeneration of:

  • Myelin sheath—fatty insulation covering on nerve fibers in the brain
  • Adrenal gland and surrounding adrenal cortex—produces vital hormones

Myelin Sheath Around Nerve Fiber

AX00010_97870_1_myelin_sheath
© 2009 Nucleus Medical Art, Inc.

There are six types of X-linked ALD:

  • Childhood cerebral ALD
  • Adolescent ALD
  • Adrenomyeloneuropathy
  • Adult cerebral ALD
  • Adrenal insufficiency-only
  • Symptomatic heterozygotes

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