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SORT1: Gene Linked to High Cholesterol

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I’ve long suspected that the reason my “bad” LDL cholesterol (low-density lipoprotein) was high had absolutely nothing to do with the cheeseburger and fries I had the night before (and the night before that) or the bowl of mint chocolate chip ice cream before bedtime or the even my Mama’s apple pancakes with extra butter and syrup for breakfast. No, anything quite so delectable as these tasty concoctions could not possibly be bad for you. So logically, the reason behind my constant cholesterol battle must certainly be simply because I was born that way. The culprit is clear - it’s all in my genes!

I’ve supported my theory with the “evidence” of a friend who is at ideal weight, eats healthier than the most fervent health nut you’ll ever find and yet two years ago, she suffered a cardiac event. You probably know someone like that as well - healthy and yet hit by heart disease seemingly out of the blue. Or, on the flip side, you may know someone whose lifestyle makes you think that they should be walking around hooked up to an auto-heart shock machine only to find out that their cholesterol is perfect. What’s up with that anyway?

What’s up with that is a gene called sortilin (SORT1). SORT1’s “job” is to help rid the liver of cholesterol. Think of SORT1 as a conductor which tells the liver not only when to release cholesterol into the blood stream but how much to release as well. If SORT1 tells the liver to release too much cholesterol, then regardless of other factors (such as diet), your cholesterol levels will be high.

European researchers recently confirmed this in animal studies and their findings will be presented in the September issue of Cell Press. As a part of the study, researchers created mice which lacked the SORT1 gene. These sweet little furry SORT1-free subjects were then fed a mouse diet designed to mimic our Western diet (you know - foods high in fat like ice cream, cheeseburgers and those great apple pancakes). When SORT1 was removed from the picture, cholesterol levels dropped by 20 percent, even with the Western high-fat diet. The SORT1-free mice also much less plaque build-up in their arteries - 60 percent less, in fact.

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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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