Adenosine monophosphate (AMP) is a substance the body creates on the way to making adenosine triphosphate (ATP), a source of energy used throughout the body. ATP is so ubiquitous in the body it is sometimes called the body’s “energy currency.”
There is no nutritional requirement for AMP, because the body manufactures it from scratch.
A typical recommended dose of AMP is 100–200 mg daily. However, it is not clear that AMP can be absorbed orally, and most studies have involved an injected form of the substance.
In adults, infection by the virus herpes zoster can cause a condition known as shingles. The initial shingles attack generally abates in a couple of weeks, but symptoms can go on to become chronic. This condition is called post-herpetic neuralgia (PHN). Some evidence hints that people with herpes zoster infection may have lower than normal levels of AMP. On this slim basis, AMP has been studied as a possible treatment for initial shingles symptoms as well as for preventing PHN.
However, this was a preliminary study, and more evidence is needed before AMP can be considered a proven treatment for shingles or PHN. Furthermore, oral AMP has not been tried for this condition. It is questionable whether AMP taken orally actually makes it intact into the body.
Another study found weak evidence that injected AMP might be helpful for
Another open study hints that AMP, this time in an oral form, might be helpful for people with excessive sensitivity to the sun (
In the human studies performed, use of oral AMP has not been associated with any side effects. However, it has been suggested that use of supplemental AMP could potentially decrease immunity. 2
Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
Last reviewed April 2009 by EBSCO CAM Review Board
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