The adrenal glands are two glands located just above each kidney. The glands produce important hormones. These hormones regulate heart rate, blood pressure, and many other vital functions. The adrenal cortex is the outside layer of the two adrenal glands.
Cancers of the adrenal cortex are very rare. They make up 0.5-2 cases per million. The majority of these tumors produce excess hormones. The excess can alter hormonal balance.
—a type of x-ray that uses a computer to make pictures of structures inside the abdomen
MRI of the abdomen
—a test that uses magnetic waves to make pictures of structures inside the abdomen
PET scan—a test that uses radioactive glucose to identify the location of tumors in the body
Adrenal angiography and/or venography—tests that use contrast dye to help confirm the presence of tumors that may be blocking blood vessels; a blood sample may be obtained to check hormone levels
—a test that uses radiation to take a picture of structures inside the body
Once cancer of the adrenal cortex is confirmed, you will be referred to an oncologist. This type of doctor focuses on cancer.
Further testing to determine what stage (1-4) the cancer has reached. The stage of a tumor is determined by its size and how far it has spread from its point of origin. At the time of diagnosis, 30%-85% of patients are found to have cancer that has spread. The higher the stage, the more dangerous and difficult it is to treat.
Treatment depends on the stage of the tumor and your overall health. Talk with your doctor about the best plan for you.
The following methods are used to treat cancer of the adrenal cortex:
Surgery to remove the adrenal tumor. This is the first treatment approach for about 75
% of all cases. The doctor will also need to remove any surrounding tissues or lymph nodes that contains cancer cells.
These treatments tend to be less effective in treating this type of cancer. They are most often used if the cancer has spread. Chemotherapy may also be used if there is a high chance the cancer will come back.
—is the drug most often used for this type of cancer. It blocks hormone production by the adrenal gland. It also destroys adrenal cancer cells. This drug does have serious side effects.
Especially helpful in treating functional tumors of the adrenal cortex
Other hormone blocking drugs may be given if mitotane does not work.
Research of new drug and radiation therapies are under way. This includes gene and immunotherapy. Your doctor may advise you to participate in one of these trials.
If treatment is successful you will still need to be screened for reoccurrence of the cancer on a periodic basis.
There are no known preventive measures. Healthy lifestyle choices may reduce your risk for cancers of all types.
Abiven G, Coste J, Groussin L, et al. Clinical and biological features in the prognosis of adrenocortical cancer: poor outcome of cortisol-secreting tumors in a series of 202 consecutive patients.
J Clin Endo & Metab
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provided by your physician. It is neither intended nor implied to be a
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IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the
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