Some evidence suggests that the bioflavonoid naringen may interact with medications in the calcium channel blocker family, increasing blood levels of the drug.
This may necessitate a reduction in drug dosage.
Bar-Or D and Gasiel Y. Calcium and calciferol antagonise effect of verapamil in atrial fibrillation.
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Hariman RJ, Mangiardi LM, McAllister RG Jr, et al. Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses.
Guadagnino V, Greengart A, Hollander G, et al. Treatment of severe left ventricular dysfunction with calcium chloride in patients receiving verapamil.
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Salerno DM, Anderson B, Sharkey PJ, et al. Intravenous verapamil for treatment of multifocal atrial tachycardia with and without calcium pretreatment.
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Luscher TF, Noll G, Sturmer T, et al. Calcium gluconate in severe verapamil intoxication.
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Kuhn M and Schriger DL. Low-dose calcium pretreatment to prevent verapamil-induced hypotension.
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Shinozuka K, Umegaki K, Kubota Y, et al. Feeding of
extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
Yeum CH, Choi JS. Effect of naringin pretreatment on bioavailability of verapamil in rabbits.
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Please be aware that this information is provided to supplement the care
provided by your physician. It is neither intended nor implied to be a
substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER
IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the
advice of your physician or other qualified health provider prior to
starting any new treatment or with any questions you may have regarding a