Desvenlafaxine Daily May Reduce Hot Flushes in Menopause
Hot flashes can cause a variety of uncomfortable symptoms in early
Researchers from the Eastern Virginia Medical School reviewed the benefits and risks of an antidepressant drug called
About the Study
The study was a
- Desvenlafaxine 100 mg
- Desvenlafaxine 150 mg
Each week the women were asked to record the number and severity of the hot flashes. After 12 weeks, compared to their records at the beginning of the study, the women reported:
- 4.9 fewer hot flashes per week in the placebo group
- 6.3 fewer flashes per week in the desvenlafaxone 100 mg group
- 7.0 fewer flashes per week in the desvenlafaxone 150 mg group
During the first week there was a higher drop-out rate for women in the desvenlafaxine groups than the placebo groups. This was probably linked to the negative side effects of the drug, including loss of appetite,
How Does This Affect You?
This study was a follow-up to a previous clinical trial. The earlier study published in the journal Obstetrics and Gynecology, also found this drug to be effective in treatment of hot flashes. These new results seem to confirm the benefits of desvenlafaxine to relieve hot flashes.
Mild to moderate hot flashes can usually be managed through
American College of Obstetricians and Gynecologists
National Women's Health Resource Center
Speroff L, Gass M, Olivier S; Study 315 Investigators. Efficacy and tolerability of desvenlafaxine succinate treatment for menopausal vasomotor symptoms: a randomized controlled trial. Obstet Gynecol. 2008 Jan;111(1):77-87.
Archer DF, Dupont CM, Constantine GD, Pickar JH, Oliver S. Desvenlafaxine for the treatment of vasomotor symptoms associated with menopause: a double-blind, randomized, placebo-controlled trial of efficacy and safety. Am J Obstet Gynecol. 2009 Mar;200(3):238.e1-238.e10. Epub 2009 Jan 24.
Last reviewed April 2009 by
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