• Crystodigin, Lanoxicaps, Lanoxin
The digitalis drugs digoxin and digitoxin are used for congestive heart failure and other heart conditions. The concerns described below apply equally to both medications.
Supplementation Possibly Helpful, but Take at a Different Time of Day
Magnesium deficiency can increase the risk of toxicity from digoxin.
Possible Dangerous Interaction
Licorice root can lower potassium levels in the body, which can be dangerous for an individual taking digoxin.
There has been one report of an apparent elevation in digoxin level caused by the herb
(so-called "Siberian ginseng").
Possible Reduction of Effectiveness of Drug
Evidence suggests that St. John's wort may interact with digoxin, possibly requiring an increased dosage to maintain the proper effect.
Possible Harmful Effect
Uzara root ( Xysmalobium undulatum ) is used to treat diarrhea. It contains substances similar to digoxin, and may cause false readings on tests designed to measure digoxin levels. 14
17. Gurley BJ, Swain A, Williams DK, et al. Gauging the clinical significance of P-glycoprotein-mediated herb-drug interactions: Comparative effects of St. John's wort, echinacea, clarithromycin, and rifampin on digoxin pharmacokinetics. Mol Nutr Food Res. 2008 Jan 23.
Last reviewed April 2009 by EBSCO CAM Review Board
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © 2007 EBSCO Publishing All rights reserved.