The herb lobelia was originally used by Native Americans in the New England region. It was subsequently popularized by Samuel Thomson, the founder of an ideosyncratic form of medicine called Thomsonianism. The enduring popularity of lobelia is one of the legacies of this nineteenth century enthusiasm. (
The Thomsonians additionally claimed that lobelia could relax muscles and nerves. On this basis, they used it for anxiety, epilepsy, kidney stones, insomnia, menstrual cramps, muscle spasms, spastic colon, and tetanus.
What is Lobelia Used for Today?
The major active ingredient of lobelia is a substance called lobeline. It is widely stated that lobeline is chemically similar to nicotine, and on this basis it has been marketed as a stop-smoking treatment
Interestingly, chemists investigating the lobeline–nicotine myth found that lobeline may diminish certain effects of nicotine in the body, specifically nicotine-induced release of the substance dopamine. Since dopamine is believed to play a significant role in drug addiction, these findings can be taken as hinting that lobeline might be useful for
Dopamine also plays a role in cigarette addiction. For this reason, despite lobeline’s lack of similarity to nicotine, it is at least possible that lobelia could be helpful for people who wish to stop smokeing. Unfortunately, despite its widespread marketing for this purpose, there has never been any meaningful evidence that it works.
Other proposed uses of lobelia also lack supporting evidence. For example, while studies in horses have found that injected lobeline causes the animals to breath more deeply,
However, there have not yet been any human studies on these potential benefits of the herb.
Lobelia is generally sold in the form of a vinegar tincture. The typical dose of this tincture is 20 to 60 drops taken three times daily.
It is widely stated that lobelia is a dangerously toxic herb. However, herbalist Paul Bergner undertook a review of published literature and discovered that each author who described lobelia as toxic was merely quoting another author, in a kind of game of telephone going back nearly 200 years. 11 The original published reference upon which this sequence of hearsay reporting appears to have been based is a note in the American New Dispensatory of 1810, in which an “eminent physician” is quoted as stating that if a person consumes lobelia and doesn’t vomit, death will follow. The ultimate origin of this claim may have been the claims made by the prosecution in a widely publicized trial of Samuel Thomson in which he was accused of committing murder through use of lobelia.
In fact, there are no reported cases of death caused by Lobelia inflata in animals or humans. Considering how widely lobelia was used under the Thomsonians and subsequently, the concern that it reliably causes death appears to be a significant overstatement. Lobelia may present health risks, but if so, they have not been documented.
Short-term side effects that have been reported in association with lobelia include stomach pain, heartburn, nausea, vomiting, and dizziness.
The fact that lobeline restricts dopamine release suggests at least a possibility that lobelia could worsen symptoms of
Safety in young children, pregnant or nursing women, or people with severe liver or kidney disease has not been established.
8. Subarnas A, Tadano T, Oshima Y, Kisara K, Ohizumi Y. Pharmacological properties of beta-amyrin palmitate, a novel centrally acting compound, isolated from Lobelia inflata leaves. J Pharm Pharmacol . 1993;45:545–50.
9. Subarnas A, Tadano T, Nakahata N, et al. A possible mechanism of antidepressant activity of beta-amyrin palmitate isolated from Lobelia inflata leaves in the forced swimming test. Life Sci . 1993;52:289–96.
Last reviewed April 2009 by EBSCO CAM Review Board
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