MMR Vaccination and Seizure Risk in Children
Each year millions of children are vaccinated against
Febrile seizures, which are characterized by a brief jerking or staring fit that is brought on by a high fever, are quite common: approximately one out of 25 children experience at least one such seizure during their childhood. And according to the Centers for Disease Control, about one out of 3,000 MMR vaccinations result in a febrile seizure. But whether the risk of seizures is linked to other factors—such as family history of seizures, birth weight, or socioeconomic status—is not known. Another unknown is the long-term outcome of these seizures.
A new study in the July 21, 2004 issue of the
Journal of the American Medical Association
found that children who received the MMR vaccination had almost three times the risk of having febrile seizures, than those who did not, but only during the two weeks following their immunization. Additionally, the long-term rate of
About the Study
This study included data on 537,171 children born in Denmark between January 1, 1991 and December 31, 1998, who were alive at three months. The researchers searched national databases to obtain the following information on each participant:
- MMR vaccination status
- History of febrile seizures and epilepsy – for both the participant and any siblings
- Birth weight and duration of pregnancy
- Socioeconomic status
- Maternal education
The researchers followed the children through 1999 and compared incidences of febrile seizures between children who received the MMR vaccination and those who did not. They also compared the risk of seizure after vaccination among different subgroups of children, measured the recurrence of febrile seizures, and looked at whether or not a child went on to develop epilepsy.
The 82% of children who received the MMR vaccination were 2.75 times more likely to experience a febrile seizure than those who were not vaccinated—but only during the two weeks following immunization, after this there was no difference in risk.
The greatest risk of seizure following MMR vaccination was among children with a history of febrile seizures. Siblings of children with a history of febrile seizures or epilepsy also had a slightly greater risk of seizure. Interestingly, the risk of seizure increased slightly with younger age of vaccination.
The researchers also found that children who experienced febrile seizures within two weeks of MMR vaccination had a 19% increased risk of recurrent febrile seizures, but no increased risk of epilepsy.
How Does This Affect You?
These findings are consistent with previous research showing that there is a slight, but increased risk of febrile seizures in children during the two weeks following MMR vaccination. However, these febrile seizures do not appear to be related to long-term risk of epilepsy. Additionally, this study suggests that the greatest risk factors for developing a febrile seizure after MMR vaccination are personal and family history of febrile seizures.
No previous study had calculated the difference in seizure risk depending on age at vaccination, and the results of this study suggest that further research is needed to determine whether age at vaccination affects the risk of seizure, as it appeared to in this study. The American Academy of Pediatrics currently recommends that all children receive the first of two doses of this vaccine between 12 and 15 months of age.
It’s important to note that febrile seizures, although scary to a parent, are usually harmless and not associated with long-term health effects. Thus when the risk associated with seizures is weighed against the risks associated with measles, mumps, and rubella, the MMR vaccine is the safer choice.
Although the risk associated with febrile seizures is low, just to be on the safe side parents should contact a healthcare provider if they think their child is having a febrile seizure. Additionally, some health care providers suggest giving children an aspirin-free pain reliever, such as Tylenol or Ibuprofen, at the first sign of a fever during the two weeks following MMR vaccination.
Protecting Your Child Against Serious Diseases: Making Sure Kids Get All Their 'Shots'
US Food and Drug Administration
Vaccine Side Effects
Centers for Disease Control and Prevention
What are febrile seizures?
National Institute of Neurological Disorders and Stroke
Febrile Seizures after MMR and DTP Vaccinations. Centers for Disease Control and Prevention. Available at: http://www.cdc.gov/nip/issues/mmr-dtp/mmr-dtp-faqs.htm . Accessed on July 22, 2004.
Vestergaard M., Hviid A, Madsen KM, et al. MMR Vaccination and Febrile Seizures. JAMA. 2004; 292: 351 – 357.
Last reviewed Jul 23, 2004 by
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
Copyright © 2007 EBSCO Publishing All rights reserved.