Myelodysplastic syndromes (MDS) are a group of diseases that involve dysfunction of the bone marrow. Bone marrow is the tissue found within the bones; its task is to create mature blood cells from stem cells. In all forms of MDS, this normal cell-creation process is disrupted by the overproduction of clones of a single stem cell. This leads to a decrease in production of normal red blood cells, white blood cells, and platelets.
The World Health Organization has classified MDS into eight categories. Some forms are more serious than others; all of them are serious enough to require a physician’s care. Thirty percent of people with MDS develop
acute myeloid leukemia
is a cancer of the white blood cells and their parent cells. As more is learned about MDS, experts began to see it as a form of cancer.
Neutropenia occurs when there are inadequate levels of white blood cells. White blood cells fight infection. Signs of this condition include:
Frequent, unusual, or especially serious infections
Thrombocytopenia occurs when there are inadequate levels of platelets in the blood. Platelets stop bleeding by clotting the blood. Signs of thrombocytopenia include:
Bleeding easily, especially from the nose and gums
Other symptoms may include loss of appetite, weight loss, and feeling tired.
Your doctor will ask about your symptoms and medical history, and perform a physical exam. The symptoms for MDS can indicate many other conditions. Doctors have to rule out other conditions before diagnosing MDS.
Tests may include the following:
Blood test to check your red and white blood cell counts and platelet counts and to check how the blood cells look.
to check for MDS. A bone marrow biopsy is the removal of a sample of bone marrow for testing.
Your doctor may also order other tests to rule out other conditions.
Treatment for MDS depends on your age, other medical conditions, and how serious the disease is. Treatment also depends on how far along the disease has progressed to AML. Often, treatment includes relieving the symptoms of MDS. Talk with your doctor about the best treatment plan for you. You may be referred to a hematologist and an oncologist. A hematologist specializes in blood diseases. An oncologist specializes in cancer. Treatment options include:
If you have a low red blood cell, white blood cell, or platelet count, you may receive a blood transfusion. A blood transfusion is a treatment that involves receiving blood products (red cells, white cells, platelets, clotting factors, plasma, or whole blood) through a vein. The blood components may come from an unrelated donor, from a related donor, or may have been banked in advance by the recipient.
If you have a low white blood cell count, you may receive antibiotics to fight infection.
Growth factors help the bone marrow produce blood cells. The following growth factors may be used to treat MDS:
Erythropoietin (EPO) is a growth factor that helps the bone marrow produce red blood cells.
Granulocyte colony-stimulating factors (G-CSF) and granulocyte macrophage colony-stimulating factors (GM-CSF) are growth factors that help the bone marrow produce white blood cells. Pegfilgrastim (Neulasta) is a form of G-CSF that is longer acting.
Chemotherapy is the use of drugs to kill cancer cells. Chemotherapy may be given in many forms including: pill, injection, or via a catheter. The drugs enter the bloodstream and travel through the body killing mostly cancer cells, but also some healthy cells.
There are three combinations of chemotherapy drugs used to treat MDS. These combinations include:
The only cure for MDS is a stem cell transplant (SCT). A SCT starts with high-dose chemotherapy to kill the bone marrow, and is then followed by an injection of healthy stem cells. The stem cells used can come from the blood or bone marrow.
There are two types of SCT. The less common one is called an autologous SCT, and occurs when the patient is injected with her own cells after high-dose chemotherapy. The more common method is called allogeneic and occurs when a patient gets donor cells after high-dose chemotherapy.
Many doctors will only perform an SCT on a patient that is aged 50 or younger.
To help reduce your chances of getting MDS, take the following steps:
Avoid exposure to hazardous chemicals such as benzene
Myelodysplastic syndromes: a review for patients, families, friends, and healthcare professionals. Patient information page. The Myelodysplastic Syndromes Foundation website. Available at:
. Accessed September 14, 2005.
Understanding myelodysplastic syndromes: a patient handbook. Patient information page. The Myelodysplastic Syndromes Foundation website. Available at:
. Accessed September 14, 2005.
Please be aware that this information is provided to supplement the care
provided by your physician. It is neither intended nor implied to be a
substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER
IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the
advice of your physician or other qualified health provider prior to
starting any new treatment or with any questions you may have regarding a