Nonsteroidal Anti-inflammatory Drugs (NSAIDs) May Reduce Risk of Prostate Enlargement
Now, in a study to be published in the American Journal of Epidemiology , researchers report that men who used NSAIDs every day had a substantially lower risk of developing an enlarged prostate or developing moderate to severe urinary symptoms than men who were not regular NSAID users.
About the Study
The researchers studied data from 2,447 Caucasian men, ages 40-79 years, enrolled in a urinary health study. At the beginning of the study, and then every two years, the subjects reported on the presence and severity of lower urinary tract symptoms and researchers measured their peak urinary flow rates. They also recorded the names and dosage of all medications taken on a daily basis. A subset of 634 men underwent additional testing including the measurement of prostate-specific antigen (PSA) levels (a common screening test for prostate cancer), a digital rectal exam, and an
After taking age and other BPH risk factors, such as
One major weakness of this study was its observational design, which can only be used to investigate an association between NSAIDs and BPH. A clinical trial, on the other hand, would more reliably establish a cause and effect relationship between the two. In addition, the study only looked at Caucasian men, so the results may not apply to men of other races and ethnicities.
How Does This Affect You?
This study found that daily NSAID users had a reduced risk of benign prostatic hyperplasia compared to men who did not take an NSAID every day. However, more studies are needed to determine whether NSAIDs are actually responsible for the decreased BPH risk and, if so, what dosage is needed to achieve this protective effect.
Many middle-aged men take a daily NSAID to help prevent heart disease or control
However, NSAIDs carry risks of their own including
American Urological Association
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
St. Sauver JL et al. Protective association between non-steroidal anti-inflammatory drug use and measures of benign prostatic hyperplasia. Am J Epidemiol .
Last reviewed August 2006 by
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