An Option for Treating Degenerative Disc Disease
What Happens in Spinal Fusion Surgery
How the Device Works
The device consists of three components split between two parts: a metallic tapered spinal fusion cage (LT-CAGE lumbar tapered fusion device) and a bone graft substitute (InFUSE Bone Graft). The InFUSE Bone Graft consists of a protein (rhBMP-2) and a carrier for the protein. These two components are placed inside the fusion cage.
rhBMP-2 is a genetically engineered version of a naturally occurring protein that is capable of initiating bone growth or bone regeneration in specific, targeted areas in the spine. The LT-CAGE stabilizes the spine, while the rhBMP-2 stimulates bone growth and the spine fuses.
What the Evidence Says
A multicenter, randomized, two-year study was conducted with 279 people with DDD. All the participants received the LT-CAGE device. Approximately half of the people received autograft bone, and the rest received InFUSE Bone Graft. The study demonstrated that the use of the LT-CAGE device with InFUSE Bone Graft was effective for promoting spinal fusion. A thorough discussion with your doctor to discuss the risks and benefits is necessary before undertaking this procedure.
American Academy of Orthopedic Surgeons
US Food and Drug Administration
The Arthritis Foundation
Burkus JK, et al. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages.J Spinal Disord Tech. 2002;15(5):337-49.
Last reviewed June 2010 by
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