Pemphigus is a group of rare autoimmune disorders. It causes large skin blisters. The immune system normally protects against germs and other foreign invaders. In this case, the immune system mistakenly attacks your own skin and mucus membranes. There are three forms of the disease:
Pemphigus vulgaris—most common type of pemphigus; lesions may extend deep into the layers of the skin
Pemphigus foliaceus—produces more superficial lesions
Paraneoplastic pemphigus—most serious type; usually occurs in someone who has
The immune system produces antibodies. These cause the skin and mucus membranes to break out in blisters and burn-like sores. What causes the body to attack itself is not known. Sometimes a drug can cause symptoms.
Factors that increase your chance for pemphigus include:
Antibiotics (topical or oral) to treat any bacterial skin infections that occur
Viscous lidocaine mouthwash may numb the mouth and provide pain relief
Sucralfate mouthwash may coat and soothe the mouth and provide pain relief
For this procedure, whole blood is removed and the plasma is separated. The packed cells are then suspended in saline are reinjected. This is used in certain cases in combination with immunosuppressive drugs.
Good nutrition helps the body heal and fight disease. Some foods may also make your symptoms worse or trigger the onset of more sores. Some patients notice they are sensitive to garlic, onions, and leeks. Keep track of the foods that seem to cause a reaction in your skin and avoid these foods. Read the labels of all foods to make sure they do not contain small amounts of foods that can set off a reaction.
Soft diets may be necessary if you have oral lesions.
In some cases of paraneoplastic pemphigus, surgical removal of the tumor may improve the disorder or decrease symptoms.
There are no guidelines for preventing pemphigus because the cause is unknown.
Beers MH et al.
The Merck Manual of Medical Information—Home Edition
. 2nd ed. Simon and Schuster, Inc.; 2003.
Cecil Textbook of Medicine
. 21st ed. WB Saunders Co.; 2000.
Chams-Davatchi C, Esmaili N, Daneshpazhooh M, Valikhani M, Balighi K, Hallaji Z, Barzegari M, Akhyani M, Ghodsi SZ, Seirafi H, Nazemi MJ, Mortazavi H, Mirshams-Shahshahani M. Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris.
J Am Acad Dermatol
. 2007 Oct;57(4):622-8.
. 3rd ed. Mosby-Year Book Inc.; 1996.
Please be aware that this information is provided to supplement the care
provided by your physician. It is neither intended nor implied to be a
substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER
IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the
advice of your physician or other qualified health provider prior to
starting any new treatment or with any questions you may have regarding a