Prosthetic Heart Valve Thrombosis
(Prosthetic Valve Thrombosis; PVT)
Prosthetic heart valve thrombosis is a rare but serious complication of a heart valve replacement procedure
Heart Valves With Prosthetic Replacements
Prosthetic heart valve thrombosis is thought to result from an interaction between components of blood and the prosthesis or turbulent blood flow in and around the prosthesis.
The following factors may increase your chance of developing prosthetic heart valve thrombosis. If you have any of the following risk factors, tell your doctor:
- Inadequate anticoagulant therapy after a valve transplant
- Prosthesis located at the mitral valve in the heart
- Atrial fibrillation
- Drugs (eg, contraceptives)
- Cancerous tumors
Systemic diseases (eg,
systemic lupus erythematosus, inflammation and damage to various body tissues, including joints, skin, kidneys, heart, lungs, blood vessels, and brain)
- Reduced cardiac pumping (low ejection fraction)
- Shortness of breath
- Difficulty breathing while lying down
- Waking at night short of breath
- Difficulty exercising
- Chest pain, burning, or pressure
- Loss of consciousness
Your doctor will ask about your symptoms and medical history, and perform a physical exam. Tests may include the following:
Talk with your doctor about the best treatment plan for you. Treatment options include:
The first line of therapy is usually thrombolysis, which uses medications to break up abnormal blood clots.
Anticoagulant medications are used to control clotting. Anticoagulation therapy may be used alone in people with small clots that are not obstructing the heart valve.
In some cases, surgery to replace the valve may be necessary.
American Heart Association
National Heart, Lung, and Blood Institute
Canadian Heart Research Centre
Heart and Stroke Foundation of Canada
Prosthetic heart valve thrombosis. DynaMed website. Available at: http://dynamed101.epnet.com/Detail.aspx?id=165492 . Accessed February 27, 2007.
Serpi M, Schmidt KG, Kreuz W, et al. Thrombolysis of prosthetic heart valve thrombosis using recombinant tissue plasminogen activator.
2001;90(3):191-196. Available at:
Roudant R, Serri K, Lafitte S. Thrombosis of prosthetic heart valves: diagnosis and therapeutic considerations. Heart. 2007;93:137-142.
Last reviewed November 2008 by
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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