• Blue-green Algae
• Nutritional Support
The supplement called spirulina consists of one or more members of a family of blue-green algae. The name was inspired by the spiral shapes in which these plants array themselves as they grow.
Spirulina grows in the wild in salty lakes in Mexico and on the African continent. It reproduces quickly, and because the individual plants tend to stick together, it is easy to harvest. Records of the Spanish conquistadors suggest that the Aztecs used spirulina as a food source; we also know that the Kanembu people of Central Africa harvested it from what is now called Lake Chad.
This plant contains high levels of various B vitamins,
Spirulina has not been proven effective for any medical condition, and there are significant safety concerns involving all forms of blue-green algae (see
Unless you live within 35 degrees of the equator and on the shores of an alkaline lake, you will have difficulty finding spirulina anywhere but in a health food store. Most carry a number of brands of spirulina that has been dried and processed into powder or tablets.
Researchers studying spirulina's effects on health have used a variety of doses, ranging from 1 to 8.4 g daily.
There is no question that spirulina is a nutritious food, but it isn't cheap. 4 Protein can be obtained much more easily and inexpensively from legumes, nuts, grains, and animal foods; iron from dark greens, prunes, and meat; and carotenes and vitamins from standard fruits and vegetables.
Spirulina might have other specific therapeutic uses beyond general nutritional support, but the evidence supporting these recommendations is highly preliminary at best.
Manufacturers of spirulina supplements sometimes claim that the plant can reduce appetite, thereby helping overweight individuals control their food intake. However, one small
It is commonly stated that spirulina and related products can
Evidence from animal studies, preliminary human trials and one small double-blind, placebo-controlled study suggests that spirulina or other forms of algae might improve cholesterol profile.
Test tube and animal studies suggest that spirulina might have some activity against the HIV, but much more research needs to be done before we could say that spirulina is helpful against
Highly preliminary evidence suggests that spirulina or other blue-green algae products may counter allergic reactions, such as
Despite widespread publicity, there is no evidence that spirulina is useful for
What Is the Scientific Evidence for Spirulina?
There are no well-documented uses of spirulina.
Fibromyalgia is a common chronic condition whose main symptoms are specific tender points on various parts of the body, widespread musculoskeletal discomfort, morning stiffness, fatigue, and disturbed sleep. The cause of fibromyalgia is not known, and current treatments are far from completely satisfactory.
A recent study suggests that the nutritious algae
might be helpful.
A double-blind, placebo-controlled trial investigated the possible
Spirulina itself appears to be nontoxic. 25
Nevertheless, there are areas of serious concern for consumers.
Various forms of blue-green algae can be naturally contaminated with highly toxic substances called microcystins.
Some states, such as Oregon, require producers to strictly limit the concentration of microcystins in blue-green algae products, but the same protections cannot be assumed to have been applied to all products on the market. Furthermore, the maximum safe intake of microcystins is not clear, and it is possible that when blue-green algae is used for a long time, toxic effects might build up. Long-term use by children raises particular concerns, especially in light of the widely popularized, but unsubstantiated belief, that blue-green algae is useful for attention deficit disorder.
Blue-green algae can also contain a different kind of highly toxic substance, called anatoxin.
In addition, when spirulina is grown with the use of fermented animal waste fertilizers, contamination with dangerous bacteria could occur.
These researchers, however, go on to suggest that it is not prudent to eat more than 50 g of spirulina daily. The reason they give is that the plant contains a high concentration of nucleic acids, substances related to DNA. When these are metabolized, they create uric acid, which could cause
The safety of spirulina in pregnant and nursing women, young children, and individuals with kidney or liver disease has not been determined.
5. Becker EW, Jakober B, Luft D, et al. Clinical and biochemical evaluations of the alga Spirulina with regard to its application in the treatment of obesity. A double-blind cross-over study. Nutr Rep Int . 1986;33:565-574.
6. Merchant RE, Andre CA. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med . 2001;7:79-80,82-91.
8. Gonzalez de Rivera C, Miranda-Zamora R, Diaz-Zagoya JC, et al . Preventive effect of Spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat, a preliminary report. Life Sci . 1993;53:57-61.
12. Mishima T, Murata J, Toyoshima M, et al . Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis.Clin Exp Metastasis . 1998;16:541-550.
13. Ayehunie S, Belay A, Baba TW, et al . Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis).J Acquir Immune Defic Syndr Hum Retrovirol . 1998;18:7-12.
14. Hayashi K, Hayashi T, Kojima I . A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: in vitro and ex vivo evaluation of anti-herpes simplex virus and anti-human immunodeficiency virus activities. AIDS Res Hum Retroviruses . 1996;12:1463-1471.
21. Vadiraja BB, Gaikwad NW, Madyastha KM . Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R -(+)-pulegone-mediated hepatotoxicity in rats. Biochem Biophys Res Commun . 1998;249:428-431.
22. Merchant RE, Andre CA. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med . 2001;7:79-80, 82-91.
23. Merchant RE, Andre CA. A review of recent clinical trials of the nutritional supplement Chlorella pyrenoidosa in the treatment of fibromyalgia, hypertension, and ulcerative colitis. Altern Ther Health Med . 2001;7:79-80,82-91.
24. Becker EW, Jakober B, Luft D, et al. Clinical and biochemical evaluations of the alga Spirulina with regard to its application in the treatment of obesity. A double-blind cross-over study. Nutr Rep Int . 1986;33:565-574.
32. Islam MS, Rahim Z, Alam MJ, et al. Association of Vibrio cholerae O1 with the cyanobacterium, Anabaena sp., elucidated by polymerase chain reaction and transmission electron microscopy. Trans R Soc Trop Med Hyg . 1999;93:36-40.
37. Halperin SA, Smith B, Nolan C, et al. Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial. CMAJ . 2003;169:111-117.
38. Shaish A, Harari A, Hananshvili L et al. 9-cis beta-carotene-rich powder of the alga Dunaliella bardawil increases plasma HDL-cholesterol in fibrate-treated patients. Atherosclerosis . 2006 Jan 12. [Epub ahead of print]
Last reviewed April 2009 by EBSCO CAM Review Board
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