Spray Associated With Reduction in Hot Flash Frequency
Researchers at Warren Alpert Medical School of Brown University set out to determine the safety and efficacy of a low dose
About the Study
- One daily transdermal spray
- Two daily transdermal sprays
- Three daily transdermal sprays
- Placebo spray
Each spray delivered 90 microliters with 1.53 milligrams of estradiol. The trial ran for 12 weeks. Compared to the placebo group all of the estradiol groups demonstrated a decrease in hot flashes. The groups that had received two or three sprays had significant reduction in severity scores compared with their baseline. There was more than a 50% reduction in hot flash frequency by 74%-85% of the estradiol group compared to only 46% in the placebo group.
How Does This Affect You?
Many women do not need any treatment for hot flashes. If you can manage your hot flashes with lifestyle changes like exercise, avoiding triggers, and relaxation techniques, that is the preferred route. However, if the hot flashes are interfering with your daily routine the estradiol spray may be an option for you. The treatment is meant to be used for a short period of time and the dose is low.
Talk to your doctor about your symptoms and concerns. Discuss treatment options such as lifestyle changes, medication, or alternative treatments. You and your doctor can agree to a plan that works best for you.
American College of Obstetricians and Gynecologists
National Women’s Health Resource Center
Buster JE, Koltun WD, Pascual ML, Day WW, Peterson C. Low-dose estradiol spray to treat vasomotor symptoms: a randomized controlled trial. Journal of Obstetrics and Gynecology . 2008 Jun;111(6):1343-51.
Last reviewed December 2008 by
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