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Melanoma may be overlooked in cancer screening programs, because it is relatively rare. This is unfortunate because melanoma is highly curable when diagnosed early, but deadly when allowed to develop to an advanced stage. A study from Scotland shows the 5-year survival rate for females with melanoma is 95.8 percent for tumors of less than 1.0 mm thickness, but drops to 48.3 percent for tumors of greater than 4.0 mm thickness. For males, survival rates are lower by a few percentage points for all tumor thickness categories.
Melanomas are developing at an increasing rate worldwide, according to Reference 1. Fortunately, mortality rates have not increased as significantly. Early detection and treatment can be effective at curing melanoma. Epidemiological studies offer the promise of identifying where screening efforts can be most effective.
The highest rates of melanoma are reported in Australia. In Queensland, males have 55.8 cases per 100,000 subjects, and females have 41.1 cases per 100,000. In the United States, rates for non-Hispanic whites are 19.4 per 100,000 for males and 14.4 per 100,000 for females. Rates are lower in Europe. There is an association between higher rates and geography closer to the equator, so sunlight exposure is a suspected cause. However, the data are not always consistent. Switzerland, near the latitude of the U.S. - Canadian border, has slightly higher rates than the United States, with a reversal in the male to female ratio. Melanomas on the arms, trunk, and legs account for most of the increased rates. The head and neck, which have more overall sunlight exposure, have approximately constant incidence.
Genetic factors are considered important in melanoma risk, with three gene mutations identified in melanoma families. Reference 1 provides the following list of established and postulated risk factors:
1. Family or personal history of melanoma
2. Multiple nevi (moles or birthmarks), especially in individuals with over 100 nevi
3. Dysplastic nevi, with at least three
4. High exposure to sunlight before age 10
5. Pale Caucasian skin
6. Red or blond hair
7. History of at least one blistering sunburn