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Gene Test Could Predict Thyroid Cancer Risk

FRIDAY, Feb. 6 (HealthDay News) -- Scientists have identified two gene mutations that appear to predict a significant increased risk of developing thyroid cancer.

This finding could lead to early diagnosis and treatment, the researchers said. In 2008, there were 37,340 new cases of thyroid cancer and 1,590 deaths, according to the U.S. National Cancer Institute.

"We found two single nucleotides polymorphisms that confer a risk of thyroid cancer," said lead researcher Dr. Kari Stefansson, CEO of deCODE Genetics, in Reykjavik, Iceland. "When you take the risk of both of them, they have almost six times the risk of thyroid cancer that the average person has," he said.

Stefansson noted the increased risk for thyroid cancer may be due to lower levels of a hormone perhaps regulated by these genes. These mutations are associated with lower levels of thyroid-stimulating hormone, he said.

"This is important in how the cancer develops," Stefansson said. "The thyroid-stimulating hormone is involved in differencing cells in the thyroid. If you have less stimulating hormone, you have less differencing of cells in the thyroid," he said.

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