Dr. Rosen shares the tests used to diagnose B-cell lymphoma and diffuse large B-cell lymphoma and and explains how diffuse large B-cell lymphomas develop.
A diagnosis of lymphoma is made by a biopsy. Most instances of biopsy of a lymph node, on occasion the lymphoma actually arises in an organ and not in a lymph node, and you have to then biopsy the organ. A bone marrow biopsy is often included as part of the evaluation.
The majority of diffuse large B-cell lymphomas, we have no idea why this cancer occurred. There are some diffuse large cell lymphomas that appear to be associated with the Epstein-Barr virus. This is the virus that causes mononucleosis. Whether or not the virus itself causes the lymphoma, or the virus just causes the cells to replicate and then other insults occur that cause the lymphoma, is not clear.
About Dr. Steven Rosen, M.D., F.A.C.P:
Steven Rosen, M.D., F.A.C.P., is Genevieve Teuton Professor of Medicine, at the Feinberg School of Medicine, Northwestern University and Director of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and Director of Cancer Programs at Northwestern Memorial Hospital. Following his graduation with distinction from Northwestern University Medical School's Six-Year Honors Program in 1976, Dr. Rosen completed his residency in Internal Medicine at Northwestern and a fellowship in Medical Oncology at the National Cancer Institute. Dr. Rosen's laboratory research focuses on experimental therapeutics and hematologic malignancies.