I have been treated for depression for the last 14 months. I am still suffering from severe depression. I am now on 150 Desipramine. Hormone levels are normal. I tried Progesterone, when weaning off of it I had good periods of no depression. After that I have not had any good days other than the days of my periods. So my mood only improves when I am menestruating. Shouldn't I be tried on Estrogen? Dr wants to try Lupron Depot for 3 months - If it treats the depression he will then remove my ovaries. I need help and no one believes my mood improves during my period. It is obvious to me that my hormones are involved with my depression.