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The information provided here is meant to give you a general idea about each of the medications listed below. Only the most general side effects are included, so ask your doctor if you need to take any special precautions. Use each of these medications as recommended by your doctor, or according to the instructions provided. If you have further questions about usage or side effects, contact your doctor.
Medications are given to treat HIV infection and decrease the amount of virus in the body. As research continues, new drugs become available. It is extremely important to take the medications exactly as prescribed, even if the drug regimen is complicated or difficult to follow. Work with your doctor to develop a plan of treatment that can best fit your needs. This plan may change as new treatments become available.
Drugs are typically prescribed in combination. Treatment with a combination of drugs is referred to as "highly active antiretroviral therapy" (HAART). Doctors attribute longer survival and improved health in people with HIV infection to the use of HAART.
Additional drugs may be ordered to treat associated infections or cancers.
Nucleoside and nucleotide reverse transcriptase inhibitors
Non-nucleoside reverse transcriptase inhibitors
Drugs to treat or prevent opportunistic infections
In addition, combinations of some of the above medications can be prescribed as one pill.
Common names include:
Protease inhibitors interfere with HIV reproduction in the body during a late stage in the virus life cycle. This slows the growth of HIV.
Possible side effects include:
Common names include:
Nucleoside and nucleotide reverse transcriptase inhibitors interfere with HIV reproduction in the body during an early stage of the virus life cycle.
Possible side effects include:
Common names include:
Non-nucleoside reverse transcriptase inhibitors interfere with HIV reproduction in the body, slowing the spread of HIV.
Possible side effects include:
Common names include:
Fusion inhibitors interfere with HIV fusion or attachment to certain receptors on cells in the body, slowing the spread of HIV.
Possible side effects include:
Common names include:
Integrase inhibitors interfere with the integration of HIV in the nucleus of the cell, slowing the spread of HIV.
Possible side effects include:
Common names include:
CCR5 inhibitors interfere with HIV attachment to certain receptors on cells in the body, slowing the spread of HIV.
Possible side effects include:
Common names include:
Drugs may be given to prevent or treat HIV-related infections. Trimethoprim/sulfamethoxazole (TMP/SMX) and pentamidine (NebuPent) may be ordered when the number of infection-fighting cells in your immune system falls to a certain level. These drugs are given to prevent pneumonia from recurring. Foscarnet (Foscavir) and ganciclovir (Cytovene) may be used to treat cytomegalovirus eye infections.
Possible side effects depend on the drugs prescribed. They include:
Drugs do not cure HIV infection or AIDS. They are given to suppress the virus. If you are HIV-positive, but do not have symptoms of AIDS, the doctor may recommend delaying the start of medication therapy until the time is right.
Whenever you are taking medication, take the following precautions:
Call your doctor if symptoms worsen, new symptoms develop or you experience side effects. Due to the potential for adverse reactions to these drugs, it is important to visit your doctor regularly. Blood tests will likely be ordered before starting and during treatment, depending on your situation.
References:
Conn HF, Rakel RE. Conn's Current Therapy 2001 . 53rd ed. Philadelphia, PA: WB Saunders Company; 2001.
HIV/AIDS. Centers for Disease Control and Prevention website. Available at: http://www.cdc.gov/hiv/ . Updated September 2008. Accessed September 25, 2008.
HIV/AIDS. National Institute of Allergy and Infectious Diseases website. Available at: http://www3.niaid.nih.gov/ . Accessed September 25, 2008.
Noble J, Greene HL. Textbook of Primary Care Medicine . 3rd ed. St. Louis, MO: Mosby, Inc; 2000.
United States Pharmacopeial Convention. USP DI. 21st ed. Englewood, CO: Micromedex; 2001.
2/21/2008 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Mallal S, Phillips E, Carosi G, et al. HLA-B5701 screening for hypersensitivity to abacavir. N Engl J Med. 2008;358:568-579.
11/10/2009 DynaMed's Systematic Literature Surveillance DynaMed's Systematic Literature Surveillance : Intelence (etravirine). US Food and Drug Administration website. Available at: http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm180579.htm . Updated August 27, 2009. Accessed October 8, 2009.
Last reviewed October 2009 by David L. Horn, MD, FACP
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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