University of Minnesota researchers have discovered that people with high oxidation levels of the low-density lipoprotein (LDL) particle that carries cholesterol throughout the blood are much more likely to develop metabolic syndrome -- which can lead to a considerably increased risk of developing heart disease.
Researchers measured oxidized LDL in more than 2,000 generally healthy people aged 33-45 (average age 40) in an ongoing study, called CARDIA. After deleting those with metabolic syndrome, they followed the remaining 1,889 for five years. Those with the highest levels of oxidized LDL had 3.5 times the risk of developing metabolic syndrome five years later.
http://www.sciencedaily.com/releases/2008/05/080520175351.htm