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The diagnosis and prognosis of non-Hodgkin's lymphoma includes the following:
Diagnosis begins with a visit to the doctor. He or she will complete a history and physical. A biopsy will be necessary to confirm the presence of cancer cells.
The doctor will ask you about your symptoms and medical history. He or she will inquire about past infections and whether or not you have had an organ transplant. This is because people with decreased immune function are at greater risk of developing non-Hodgkin’s lymphoma, and the drugs ordered after an organ transplant to reduce the chance of rejection decrease immune function.
Non-Hodgkin’s lymphoma also seems to occur in people who have had been infected with the human immunodeficiency virus (HIV) and Epstein-Barr virus, which causes infectious mononucleosis.
The doctor also will ask you about any nonspecific symptoms you may be having. For instance, whether or not you are experiencing fatigue, changes in appetite, or night sweats.
The doctor will perform a physical exam, including checking your temperature. He or she will carefully palpate (feel while applying pressure to) the areas where lymph nodes are found. Most enlarged or swollen lymph nodes are caused by an infection, not lymphomas. If infection is suspected, you may be given an antibiotic and instructed to return for re-examination. If swelling persists, your doctor may order a lymph node biopsy.
If your doctor suspects non-Hodgkin's lymphoma, you will have a lymph node biopsy.
Lymph node biopsy – your doctor will remove all or part of one of your lymph nodes, and a pathologist will examine this tissue sample under a microscope. The biopsy may show whether or not there is cancer and the type of cancer cells present. Completely removing the lymph node is optimal. Accurate diagnosis and classification of the type of cancer depend on removal of an adequate amount of tissue, which may or may not be possible, depending on the location.
Cytology is the study of cells. The cytology of cancer cells differs significantly from normal cells, and physicians use the unique cellular features seen on biopsy samples to determine the diagnosis and assess the prognosis of a cancer.
After the biopsy, a pathologist in the laboratory will look at the type of cells within the sample under a microscope to identify its cell type. Because non-Hodgkin’s lymphoma is classified by cell type, precise classification also requires immunophenotyping. This test is used to identify the characteristics or patterns of antigens produced by the cancer cells.
In non-Hodgkin’s lymphoma, the type of cell, which is determined by the pathologist, is considered more important than the stage of the cancer in determining prognosis and expected response to treatment.
Several classification systems exist for non-Hodgkin’s lymphoma. In the United States, the two most commonly used are the Working Formulation and the REAL classification systems.
Pathologists using the Working Formulation system assess the size and shape of the cells and their growth pattern. The Working Formulation system divides non-Hodgkin’s lymphoma into three categories:
The REAL classification system stands for Revised European American Lymphoma. It is newer a system of classification. REAL classifies the types of lymphoma by how the disease behaves. Pathologists using this system assess the cells’ appearance, genetic features, and chemistry. The system also takes into account what normally happens to patients with the disease. The REAL classification system divides non-Hodgkin’s lymphoma into four categories:
Staging is the process by which physicians determine the prognosis of a cancer that has already been diagnosed. Staging is essential for making treatment decisions (e.g., surgery vs. chemotherapy). Several features of the cancer are used to arrive at a staging classification, the most common being the size of the original tumor, extent of local invasion, and spread to distant sites (metastasis). Low staging classifications (0 – 1) imply a favorable prognosis, whereas high staging classifications (4 – 5) imply an unfavorable prognosis. If cancer is found, your prognosis and treatment depend on the location, size, and stage of the cancer as well as your general health.
Your doctor will consider the following factors to determine the stage of your disease:
Additional tests to determine staging may include:
The following stages are used to classify non-Hodgkin’s lymphoma:
Stage I – Cancer involves a single lymph node region. Or if the cancer started in an organ, it is limited to that organ.
Stage II – Cancer has spread to two or more lymph node regions on the same side of the diaphragm. Or if the cancer started in an organ, it has spread to one or more lymph node groups on the same side of the diaphragm.
Stage III – Cancer has spread to both sides of the diaphragm.
Stage IV – Cancer has spread to organs other than lymph nodes with or without diseased lymph nodes.
Stages have an “A” and a “B” level. In Stage B, a person with non-Hodgkin's lymphoma experiences general symptoms from the disease—fever, night sweats, or significant weight loss. If these specific symptoms are not present the classification is "A."
The third stage has an “S” or “SE” level. The S refers to involvement of one organ or the spleen. SE refers to both one organ and the spleen.
Prognosis is a forecast of the probable course and/or outcome of a disease or condition. Prognosis is most often expressed as the percentage of patients who are expected to survive over five or ten years. Cancer prognosis is a notoriously inexact process. This is because the predictions are based on the experience of large groups of patients suffering from cancers at various stages. Using this information to predict the future of an individual patient is always imperfect and often flawed, but it is the only method available. Prognoses provided in this monograph and elsewhere should always be interpreted with this limitation in mind. They may or may not reflect your unique situation.
Doctors use an international prognosis index to predict how the cancer will respond to treatment. The index helps doctors plan treatments. The index includes the following factors:
Age – whether you are younger or older than 60; one point is assigned for over 60
Stage – one point is assigned for stage III or IV
Whether the lymphoma is evident outside the lymph nodes – one point is assigned for disease outside the lymph nodes
Patient’s ability to function normally, despite the tumor – one point is assigned if you need help with activities of daily living
Blood test for LDH, which is elevated with fast-growing tumors – one point is assigned if the LDH level is elevated
With this system, the lower the score the better the prognosis. More than 75% of the people in the lowest group will survive for five or more years. Of the people with the poorest (highest) scores, only 30% live for five years or more.
Sources:
Abeloff, M. Clinical Oncology , 2nd ed., Orlando, FL: Churchill Livingstone, Inc.; 2000: 2658-2701.
American Cancer Society
National Cancer Institute
Rakel, R. Conn's Current Therapy 2002 , 54th ed., St. Louis, MO: W. B. Saunders Company; 2002: 434-439.
The Leukemia & Lymphoma Society
Last reviewed February 2003 by Francine Foss, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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