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When my children were small and due for their shots, the doctor's office advised giving them acetaminophen drops before getting a vaccination. Some years before that the usual routine was to give a child some baby aspirin before shots but Reye's syndrome put a sudden stop to that practice.
According to some research from the University of Defence in Hradec Kralove, Czech Republic, it would appear that acetaminophen used to reduce any fever from a vaccination should go the way of baby aspirin.
Research reported in the October 17, 2009 edition of The Lancet that children aged 3 to 5 months who had been given acetaminophen before some immunizations had decreased immune response. The vaccines reported were for diphtheria, haemophilus influenza type B (Hib), pertussis, pneumococcal disease and tetanus.
Diphtheria is a bacterial infection that affects the nose and throat. Early symptoms are fever and swollen glands in the neck. Continuing infection can cause double vision, slurred speech and problems in breathing or swallowing,
Haemophilus influenza type B (Hib) can cause bacteremia, pneumonia and acute bacterial meningitis in children. It can also cause cellulitis, epiglottitis, infectious arthritis and osteomyelitis.
Pertussis is also known as whooping cough and affects the respiratory system. In children, pertussis usually starts with a cough, fever and runny nose.
Pneumococcal disease is caused by bacteria that can invade the lungs, the bloodstream, and the brain.
Tetanus, also called lockjaw, is caused by a bacteria that enters the body through a wound. Painful muscle spasms lead to problems such as drooling, problems with swallowing and opening the mouth.
Children aged 12 to 15 months, who had acetaminophen after booster shots for Hib, pneumococcal disease and tetanus still had diminished immune responses.
A Eurekalert! public release from December 1, 2009 referred to research from the University of Missouri indicating that aspirin and acetaminophen have an inhibiting effect on enzymes which then render some vaccines less effective.
Aspirin and acetaminophen seem to deter the enzyme COX-1 from doing its job in body tissues.