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How safe is Estrace cream for vaginal dryness?

By Anonymous August 22, 2011 - 7:40am
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My doctor recently prescribed this cream for me, but I have a hx of family cancer including breast cancer so I have concerns about the intake of estrogen into my system. I didn't know how much of the medicine is absorbed into the blood stream and I was also wondering which form of estrogen is in the cream, E1, E2, or E3?

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Hi Anon,

When I looked up Estrace for you, the first Warning that came up was this one: Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus [womb]). The longer you use estrogen, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy (surgery to remove the uterus), you may be given another medication called a progestin to take with vaginal estrogen. This may decrease your risk of developing endometrial cancer, but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using vaginal estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with vaginal estrogen. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment.

Use your better judgement if you have a family history of cancer.


I do not know if it is E1, E2, or E3-- you should consult your doctor if it is a concern.

Hope this helps,


August 22, 2011 - 8:26am
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