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Amyloidosis - An Overview Of This Rare Disorder (And The Amyloid Hypothesis)

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Amyloidosis - An Overview Of This Rare Disorder

As there are many types of amyloidosis, it is hard to specify a treatment. It does entirely depend on the type of disease and the organ(s) affected. Treatment may include one of the following:

• Chemotherapy with stem cell transplant to damage the abnormal bone marrow cells and stop them from making the abnormal proteins (mostly for those with AL amyloidosis)
• Steroids (mostly for secondary, AA amyloidosis, but can certainly be done in conjunction with chemotherapy)
• Liver or kidney transplant

• Dietary restrictions
• Compression stockings (to help with swelling)

Alzheimer’s patients have an unusual build-up of amyloid in their brains. However, drugs that have helped remove the protein have not helped to slow the onset of dementia. Large clinical trials are currently underway that will test amyloid drugs on Alzheimer’s patients, either to close the amyloid hypothesis for good or to find mounting evidence that the two are related. At the present time, there are no drugs for amyloid that also target Alzheimer’s. (4)

There is a lot to discover within this multi-factor disease. Many scientists and doctors are churning out new articles and new clinical trials regularly, in the hope that there will be more clear answers and clear treatment in the future.

 

 

1.    Amyloidosis. The Mayo Clinic. https://www.mayoclinic.org/diseases-conditions/amyloidosis/symptoms-causes/syc-20353178Retrieved 14 February 2019.

2.    Amyloidosis. WebMD. https://www.webmd.com/cancer/lymphoma/amyloidosis-symptoms-causes-treatments#1Retrieved 14 February 2019. 

3.    Amyloidosis: Rare Disease Database. National Organization For Rare Disorders. https://rarediseases.org/rare-diseases/amyloidosis/ Retrieved 14 February 2019.

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4.    Zhang, Sarah. Is The Leading Theory About Alzheimer’s Wrong? The Economist. https://www.theatlantic.com/health/archive/2017/02/alzheimers-amyloid-hypothesis/517185/Retrieved 14 February 2019.

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Anonymous

Why no mention of the other types of amyloidosis? (hATTR & countless subtypes not so easily treated though new RNAi drugs could help)

February 26, 2019 - 7:56am
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We value and respect our HERWriters' experiences, but everyone is different. Many of our writers are speaking from personal experience, and what's worked for them may not work for you. Their articles are not a substitute for medical advice, although we hope you can gain knowledge from their insight.

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