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AUDIO: Dr. Jill Siegfried - Is Lung Cancer More Fatal In HRT Recipients?

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So as soon as we found out about this and started to look for that in lung tumors, we found it expressed very, very often, actually in lung tumors from women and some from men.

So then we started to study whether if we treated lung cells, lung tumor cells in the laboratory with hormones would we increase their growth rate, and we found that we did, and then we studied it in animals. We made lung tumors in animal, in mice and we asked if we gave those mice estrogen pellets that would release estrogen into their bloodstream would the tumors grow faster, and they did.

And now we have been actually studying the idea that the tumor itself can actually make estrogen in its own local environment and act back on the receptor, which has been found in breast cancer as well. So we think that the lung tumors can grow faster and metastasize, get more aggressive, both from circulating estrogens that might come, say, from hormone replacement therapy and from estrogen that these tumors can actually make right in the lungs.

Wow! That is just so fascinating. So before you can figure out how to cure the lung cancer you’ve got to figure out what’s creating it.

Dr. Jill Siegfried:

And it sounds like you are really on the forefront there.

Dr. Jill Siegfried:
Yes, and we have actually got two clinical trials going on where we are trying to use some of the same anti-estrogen drugs that have been used for breast cancer in women that have lung cancer, and we are in the middle of doing this. I can’t really tell you the results yet because we are not, we have several years to go before we can really tell what’s going on, but I am hopeful that we will be able to show effects of these drugs and that we may be able to take all the things that were learned clinically for breast cancer and start using those drugs for lung cancer.

Now I know that there are women that are estrogen…

Dr. Jill Siegfried:


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