• ]]>High Cholesterol]]>
Guggul, the sticky gum resin from the mukul myrrh tree, plays a major role in ]]>Ayurveda]]> , the traditional herbal medicine of India. It was traditionally combined with other herbs for the treatment of arthritis, skin diseases, pains in the nervous system, obesity, digestive problems, infections in the mouth, and menstrual problems.
What Is Guggul Used for Today?
Other potential uses of guggul have no more than minimal supporting evidence. One small study hints that guggul might be helpful for ]]>acne]]> . ]]>6]]> In addition, a study in mice found potential ]]>anti-diabetic]]> effects. ]]>7]]>
Recently, guggul has been promoted as a ]]>weight-loss]]> agent. Supposedly, it works by enhancing thyroid function. However, there is little evidence that guggul actually affects the thyroid, and one small ]]>double-blind, placebo-controlled]]> trial failed to find it effective for weight loss. ]]>8]]>
What Is the Scientific Evidence for Guggul?
One of the positive placebo-controlled studies enrolled 61 individuals and followed them for 24 weeks. ]]>9]]> After 12 weeks of following a healthy diet, half the participants received placebo and the other half received guggul at a dose providing 100 mg of guggulsterones daily. The results after 24 weeks of treatment showed that the treated group experienced an 11.7% decrease in total cholesterol, along with a 12.7% decrease in LDL ("bad" cholesterol), a 12% decrease in triglycerides, and an 11.1% decrease in the total cholesterol/HDL ("good" cholesterol) ratio. These improvements were significantly greater than what was seen in the placebo group.
Similar results were seen in a double-blind, placebo-controlled trial of 40 individuals. ]]>10]]>
A double-blind study of 228 individuals given either guggul or the standard drug clofibrate found approximately equal efficacy between the two treatments. ]]>11]]> However, the absence of a placebo group makes these results less than reliable.
In contrast to these results, a double-blind, placebo-controlled study of 103 people failed to find guggul effective at a dose of 75 mg or 150 mg of guggulsterones daily. ]]>15]]> In fact, the herb seemed to worsen levels of LDL ("bad") cholesterol. The reason for this discrepancy is not clear.
A small controlled trial compared oral gugulipid (50 mg of guggulsterones twice daily) against tetracycline for the treatment of ]]>acne]]> and reported equivalent results. ]]>6]]> Unfortunately, the study report does not state whether this trial was double-blind, and it also lacked a placebo group. (For information on why this matters, see ]]>Why Does This Database Rely on Double-blind Studies?]]> )
Guggul is manufactured in a standardized form that provides a fixed amount of guggulsterones, the presumed active ingredients in guggul. The typical daily dose should provide 100 mg of guggulsterones.
In clinical trials of standardized guggul extract, no significant side effects other than occasional mild gastrointestinal distress or allergic skin rashes have been seen. 12,13-15]]> Lab tests done in the course of these trials did not reveal any alterations in liver or kidney function, blood cell numbers and appearance, heart function, or blood chemistry.
Drugs in the ]]>statin family]]> used to reduce cholesterol can cause a potentially serious condition called rhabdomyolysis, in which muscle fibers break down. One case report hints that this could occur with guggul, as well. ]]>16]]>
Safety in young children, pregnant or nursing women, or those with severe liver or kidney disease has not been established.
4. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther . 1994;8:659-664.
9. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther . 1994;8:659-664.
13. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther . 1994;8:659-664.
Last reviewed April 2009 by EBSCO CAM Review Board]]>
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