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Dr. Sarrel describes how a woman can maintain a steady estradiol level.
Dr. Sarrel:
Estradiol, which is the key estrogen, remember that the ovaries we’re making all of her life, can now be made in a factory. It’s extracted from yams, and it’s extracted from soy, so in fact you can make the hormone exactly that a woman’s body has been accustomed to all of her life.
Now, she can receive it; she can take it in a variety of forms, as a pill or as a non-oral preparation. There’s a vaginal cream with estradiol, there’s a skin patch with estradiol, there’s a gel with estradiol, there’s a spray with estradiol.
In our experience at Yale, our best success in trying to achieve a steady state in the delivery of estradiol has been with estradiol skin patches, and as the patches have improved, what we have seen that works best right now is not a generic patch. They don’t work very well at all, but an FDA-approved patch that’s changed twice a week, which has a wide range of dose levels. So in fact, you can tailor it to the woman’s needs.
About Dr. Sarrel, M.D.:
Philip M. Sarrel, M.D., completed his medical education at New York University School of Medicine, his internship at the Mount Sinai Hospital, and his residency at Yale New Haven Hospital. In addition to his many years on the faculty of the Departments of Obstetrics and Gynecology and Psychiatry at Yale University School of Medicine, Dr. Sarrel has also been a Faculty Scholar in the department of psychiatry at Oxford University, Visiting Senior Lecturer at King’s College Hospital Medical School at the University of London, Visiting Professor in Cardiac Medicine at the National Heart and Lung Institute in London, and Visiting Professor in the Department of Medicine at Columbia University College of Physicians and Surgeons in New York. He is currently Emeritus Professor of obstetrics, gynecology, and psychiatry at Yale University.