I have been taking 125mcg of synthroid for 4 years and yet the symptoms are still affecting my lifestlye. I have quit taking the medication two months ago and feel better than I have in a very long time. I believe that I am being treated wrong for my condition. I have explained to my doctor time and time again that I wanted to explore other alternatives for treatment but he refuses to. He says there is no other alternative, and the other meds will not make a difference if we switch them. I am very concerned for my health. I am only 28 and there is no one else in my family with this condition. I believe that I am on an extremly high dose and that it may be one issue. I understand that medication is needed but do not understand while I am medicated why the symptoms are still here. Can anyone shed some light on this for me? Symptoms include: fatigue, severe weight gain, dry skin, intolerance to cold, severly abnormal menstral cycles, decreased sex drive, depression, irritability, and muscle cramps.