I started taking the pellets in 2006 and have always felt wonderful. I always felt so wonderful using the pellets and SO AWFUL as their effects diminished (4-6 months depending on my relative stress) that I was concerned about going off. At the time my physican commented that I could do hormones for the rest of my life if I needed them. Now she's changed her tune (2011) and says I need to wean off. I can already feel the effects (screetchy moods, poor sleep) of my pellet running out and I'm feeling a little panicked