I am taking 150 mg desipramine, 1.0 mg Clonazepam, 30 mg Temazepam, 10 mg of Paroxetine and Yasmin. I have had a stress test and will be hooked up to a holter monitor for a day soon. I am wondering if decreasing the desipramine would lower the heart rate. If is does, how long would it take. I tried lowering by 50mg for a week and there wasn't really any change. Dr has recommended taking Propranolol to decrease heart rate (around 120 for normal and goes up with exercise). I don't want to take another drug to treat the side effects of another.