I have both disorders and sometimes I cannot tell the difference between the fatigue of MG, which is occasionally relieved by rest, and the fatigue of CFS, which occurs without activity and sometimes with but doesn't seem to go away, even after a nights sleep. But I also have sleep apnea and don't get restorative sleep. I just found out my new BIPAP machine is not doing me any good in relieving the apnea episodes. They tested me to see if I need to go back on night-time oxygen. It is the chronic fatigue and frequent shortness of breath that are bothering me the most. I may have asthma and I do have COPD. Lately I have not been anemic, though I have spent most of my adult life anemic. Depression is also an issue. How do I differentiate from all of these problems and symptoms so I can treat them better. So far not much has helped. I have to spend a great deal of time in bed because I don't have the energy or strength to do anything. When the weather is nice I do walk and despite the exhaustion and shortness of breath I do do the housework. I take frequent breaks as they are required. If someone can help me sore some of this out I would be greatly appreciated. Thank you. bbnrse P.S. I should also add that I am hypothyroid. I also have fibromyalgia.