I'm a 62 year old woman who sailed through menopause at 51 with the use of 15 mg. of progesterone per day. No sleep troubles and a cast iron stomach. My estrogen has since always tested low. In the past 2 yrs. I have developed severe insomnia, hypothyroid symptoms, high cortisol, GI issues, muscle tension (particularly in my stomach), palpitations, left lower abdominal pain, low grade anxiety, etc. Have seen a couple of doctors who offered only sleeping pills and antidepressants. Another has started me on compounded PLO gel, 1 mg. estriol + .25 mg. estradiol + 20 mg. progesterone, applied to labia/entrance to vagina. Now on my 8th day and insomnia has gotten way worse, if that's possible! Is this a case of symptoms getting worse until the 4th week? I've also been tried on Nature-Throid, but as I raised it, my symptoms came back at 1-1.5 gr., so I am now only on 1/2 gr. By the way, doctors consider my TSH to be normal. I also am seeing a DOM acupuncturist; he is treating me with herbs for high cortisol. Is it possible that the high cortisol is the underlying problem for low sex hormones, thyroid resistance, GI problems, and severe insomnia? Any help is appreciated; I am hoping for some relief soon. Doctors in Las Cruces, NM seem not to have a clue, and I need to know I'm on the right track. Kathy B.