Steve, a 42-year-old computer consultant, was frequently told that his eyes were red. Because of the redness and because his eyes often felt dry and uncomfortable, Steve visited his eye doctor, who made a diagnosis of dry eye syndrome. When Steve casually mentioned that he was also having trouble with some stiffness in his joints, the eye doctor wasn't surprised. He knew what Steve didn't—dry eyes can be related to autoimmune diseases, such as rheumatoid arthritis.
Dry eye syndrome and rheumatoid arthritis (RA) affect millions of people worldwide, and both can be painful and debilitating. Both conditions can interfere with numerous aspects of daily living such as reading, working on the computer, or participating in outdoor activities.
Dry eye syndrome—clinically known as keratoconjunctivitis sicca is a decline in the amount or quality of tears that bathe the eyes. Tears protect against eye infections and are important for normal eye health. If your tears are of poor quality for whatever reason your eyes will water excessively to compensate. Pain and redness are not necessarily related to dry eye syndrome, but should be checked by an eye doctor. Although the symptoms of dry eye syndrome can come and go, they become more persistent as the condition worsens.
Anything that interferes with tear production can lead to dry eye syndrome. Some of the most common causes include:
The symptoms of dry eye syndrome include:
Rheumatoid arthritis
Because people with dry eye syndrome have more rheumatoid factor in their blood than people without dry eye syndrome, doctors believe that dry eyes may be connected with rheumatoid arthritis (RA). Some doctors consider dry eye syndrome to be a complication of RA. Of all people with RA, 18-38% have dry eye syndrome. But the development of dry eye syndrome doesn't predict the severity or duration of RA. And it's important to remember that although there are many types of arthritis, only rheumatoid arthritis is associated with dry eye syndrome.
RA is characterized by joint inflammation that causes pain, stiffness, warmth, redness and swelling and usually affects the wrist, hand joints, elbows, shoulders, neck, knees, hips, and ankles. The onset of RA in adults is usually between the ages of 40 and 60, although it can occur in children and younger adults as well. The pain and inflammation can be chronic—over a prolonged period of time—or intermittent, with flare-ups from time to time. The diagnosis of RA is made via physical exam and a blood test for rheumatoid factor.
Sjogren's syndrome
In Sjogren's syndrome, the body's immune system turns against itself and attacks glands that produce moisture, such as tear glands in the eyes and saliva glands in the mouth. It affects approximately two to four million Americans. Symptoms include:
RA and dry eye syndrome can get progressively worse, and over time, can cause permanent damage. Untreated RA can lead to loss of movement and deterioration in lifestyle, and untreated dry eye syndrome can lead to loss of vision.
At this time, there is no known cure for either dry eye syndrome or RA.
Here's how to protect your eyes by preventing tears from evaporating:
Seek medical attention if:
RESOURCES:
American Academy of Ophthalmology
http://www.aao.org
National Eye Institute
http://www.nei.nih.gov/
CANADIAN RESOURCES:
Canadian Family Physician
http://www.cfpc.ca/cfp/
Canadian Ophthalmological Society
http://www.eyesite.ca/
References:
Dry eye syndromes. Schepens Eye Research Institute website. Available at: http://www.eri.harvard.edu/htmlfiles/dryeye.html.
Stern ME, et al. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17(6):584-589.
Uhlig T, et al. Sicca symptoms, saliva and tear production, and disease variables in 636 patients with rheumatoid arthritis. Ann Rheum Dis. 1999;58:415-422.
Last reviewed January 2008 by Alexander J. Anetakis, MD
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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