Mesalamine is used to treat ulcerative colitis (a condition in which part or all of the lining of the colon [large intestine] is swollen or worn away). Mesalamine delayed-release tablets and controlled-release capsules may be used to treat ulcerative colitis that affects any part of the colon. Mesalamine suppositories and enemas should only be used to treat inflammation of the lower part of the colon. Mesalamine is in a class of medications called anti-inflammatory agents. It works by stopping the body from producing a certain substance that may cause pain or inflammation.
Mesalamine comes as a delayed-release tablet and a controlled-release capsule to take by mouth and as a suppository and an enema to use in the rectum. The delayed-release tablet is usually taken three times a day, and the controlled-release capsule is usually taken four times a day. The suppository is usually used one to three times a day, and the enema is usually used once a day at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take or use mesalamine exactly as directed. Do not take or use more or less of it or take or use it more often than prescribed by your doctor.
Swallow the tablets whole; do not split, chew, or crush them. Be careful not to break the protective coating on the tablets.
If you are unable to swallow the capsules, you may mix the contents of the capsules with water. Open a capsule and sprinkle all of the beads it contains in a small glass of water. Stir the beads into the water and drink the mixture right away. Do not store mixtures of beads and water for later use.
The enema and suppositories are for rectal use only.
You should begin to feel better during the first few days or weeks of your treatment with mesalamine. Continue to take or use mesalamine until you finish your prescription, even if you feel better at the beginning of your treatment. Do not stop taking or using mesalamine without talking to your doctor.
Mesalamine suppositories and enemas may stain clothing, flooring, fabric and other surfaces. Take precautions to prevent staining when you use these medications.
If you are to use the enema, follow these steps:
If you are to use the suppository, follow these steps:
If you will be using mesalamine enemas or suppositories, ask your pharmacist or doctor for a copy of the manufacturer's information for the patient that comes with the medication.
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Before taking or using mesalamine,
Unless your doctor tells you otherwise, continue your normal diet.
Take or use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take or use a double dose to make up for a missed one.
Mesalamine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
Mesalamine may cause other side effects. Call your doctor if you have any unusual problems while you are taking or using this medication.
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat, light, and moisture (not in the bathroom). You may store mesalamine suppositories in the refrigerator but do not freeze them. Once you open the foil package of mesalamine enemas use all the bottles promptly, as directed by your doctor. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
If you are taking mesalamine delayed-release tablets, you may notice the tablet shell or part of the tablet shell in your stool. Tell your doctor if this happens several times.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests before and during your treatment.
Do not let anyone else take or use your medicine. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Please be aware that this information is provided to supplement the care provided by your physician. It is neither intended nor implied to be a substitute for professional medical advice. CALL YOUR HEALTHCARE PROVIDER IMMEDIATELY IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with any questions you may have regarding a medical condition.
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