I had complete hysterectomy in 2007. i have tried estrogen and progesterone pills, creams, and estrogen patches. I developed bone pain, fatigue, weight gain, and depression. When I had my hysterectomy, i was seeking relief from menstrual agony. After living the next two years in misery, I decided i had enough. In 11/09 i received sottopellet injections. i immediately had an improvement in energy and feeling of well being. The downside is the occasional mood swings. I now have severe acne and my hair is thinner than normal as if it is falling out. I have been hypothyroid for 17 years and on synthroid daily. Im aware this may cause some hair loss but it seems to have worsened after getting the pellet injections.