I have posted previously about trigger points, upper extremity pain, numbness and tingling, and this is just another lovely symptom to go along with the entire mess. For instance, I was doing yardwork yesterday and today (this is not unusual for me, I'm a fairly active person), and my body is acting as if I just ran a road-race. My muscles are sore, and I feel like the tissues and fluids in my body are totally inflamed - almost like a bloated feeling. Sometimes I can actually feel it swelling. My doctor (a rheumatologist), says it's just a viscious circle..the muscles get tweaked, pain and inflammation, trigger points, pain and tingling, and over and over it goes. Why in the world does such a small amount of activity produce such a huge reaction? My doctor just raised my Pristiq dose to 100mg/day, but I'm still having pain and exaggerated symptoms.