American and Canadian researchers have linked proton pump inhibitors (PPIs) to higher risk of fractures. Other research report a possible connection between PPIs and greater risk of infection from the C. difficile bacterium.
The proton pump inhibitors in question are Aciphex, Dexilant, Nexium, Prevacid, Prilosec, Protonix, Vimovo and Zegerid. According to the FDA, these types of drugs can cause higher risk of fractures of hips, wrists and spine.
"The drugs all are proton pump inhibitors (PPIs), the most powerful class of antacid drugs. It's the third highest-selling class of drugs in the U.S. Each year, doctors write 113.4 million prescriptions for the drugs. Three -- Prevacid, Prilosec, and Zegerid -- are available without prescription."
Those who are on very high doses or are on PPIs for more than one year are at higher risk of fractures. Over-the-counter PPIs should not be taken for more than a 14 day course. These 14 day courses should not exceed three courses in a year.
http://www.webmd.com/heartburn-gerd/news/20100525/fda-warns-of-fracture-risk-from-acid-reflux-drugs?ecd=wnl_hbn_053110